REACTION OF ISONIAZID (INH) WITH RHENIUM (Re) USING DIFFERENT REDUCING AGENTS, CHARACTERIZATION OF COMPLEXES AND X-RAY CRYSTAL STRUCTURE OF INH DIMER
Abstract
Reactivity of INH with NH4ReO4 was studied using SnCl2•2H2O and NaBH4 as reducing agents. 99mTc labelled INH was also prepared according to the reported procedure for comparison. A complex (1) similar to 99mTc-INH (2) was formed with NH4ReO4 in the presence of SnCl2•2H2O. On the other hand, NaBH4 gave a dimer of INH (3) which was confirmed by x-ray crystallography. The products, 1, 2 and 3 were characterized by HPLC, IR spectra and x-ray crystallography.References
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